RESOLV chemist Guido Clever has just synthesized two nano objects showing unprecedented structures and properties. One object has two cavities, resembling the shell of a peanut. Another object has a complex chain-like structure and can bind to DNA.
The role of the solvent in the process is significant: Acetonitrile, a polar solvent, mediates the reaction between the organic components and the metal cations (palladium) involved in the process.The interaction with biomolecules like DNA suggests that these compounds may be used as potential diagnostic or therapeutic tools. The results have been reported as a VIP paper in the renowned journal ‘Angewandte Chemie International Edition’.
R. Zhu, I. Regeni, J. J. Holstein, B. Dittrich, M. Simon, S. Prévost, M. Gradzielski, G. H. Clever: "Catenation and Aggregation of Multy-Cavity Coordination Cages", in: Angew. Chem. Int. Ed. 2018, DOI: 10.1002/anie.201806047