Däschlein-Gessner Group

Optimization of phosphines for palladium catalyzed coupling reactions

About the topic:

Phosphines are ubiquitously used as ligands in palladium catalyzed coupling reactions. In particular, electron-rich phosphines have shown to be beneficial in this application due to their ability to accelerate the often rate-limiting oxidative addition. We have recently introduced the family of ylide-substituted phosphines, which owing to their strong donor ability perform excellently in many transformations with strong nucleophiles. However, difficulties were experienced with weak nucleophiles, with which transmetallation often becomes the slowest step within the catalytic cycle. This requires further tuning of the ligand design as well as reaction conditions such as the solvent and additional additives.

What they are looking for in students:

We are looking for students either interested in

a) the synthesis and application of new phosphine-based catalysts (requires experience in lab work including the handling of air-sensitive compounds and their characterization)


b) the in silico design of catalysts using predictions based on machine learning techniques (requires knowledge in DFT studies and programming (python))

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Paper related to the topic

HOW To Apply

Apply here

For your application you will need:

  • CV with contact details and affiliation (max. 2 pages)
  • letter of motivation related to Solvation Science (1 page)
  • your research proposal (1 page)
  • your diploma (Bachelor or Master)

Prerequisites: Current Master and PhD students with expiriences in Natural Sciences, Medical Sciences or related topics of Engineering

Start: 09th October 2023

Deadline: 01st June 2024



Win A research Stay

Subject: conduct your research proposal
Duration: 3 months
Location: Bochum, Germany and local Ruhr RESOLV partner institutions
Language of instruction: English
Costs: RESOLV sponsors travel and a monthly stipend
Period research stay: before August 2025