
Sánchez García Group
Computational engineering of enzymes: Optimizing the stability and activity of Alpha-amylase in organic solvents for the bioremediation of n-alkanes
About the group:
We are the Computational Bioengineering group at the Biochemical and Chemical Engineering department of the TU Dortmund University. The implementation and application of novel computational tools are central to our research. We focus on free energy, multiscale and machine learning-based tools, including our CL-FEP1 approach and the PPI-Detect2 and PPI-Affinity3 tools. On the application side, we focus on solvation chemistry, biocatalysis, chemical reactivity and computer aided drug design.
What they are looking for in students:
-Chemistry and biochemistry knowledge, with emphasis on protein engineering and biocatalysis
-Sound theoretical knowledge and applied skills on structure prediction and biomolecular simulations: homology models, docking techniques, molecular dynamics simulations, free energy calculations, computational mutagenesis
-Knowledge of Linux and basic scripting





HOW To Apply
For your application you will need:
- CV with contact details and affiliation (max. 2 pages)
- letter of motivation related to Solvation Science (1 page)
- your research proposal (1 page)
- your diploma (Bachelor or Master)
Prerequisites: Current Master and PhD students with experience in Natural Sciences, Medical Sciences or related topics of Engineering
Start: 09th October 2023
Early Bird Deadline: 31st December 2023
Deadline: 01st June 2024
Download
Factsheet
Win A research Stay
Subject: conduct your research proposal
Duration: 3 months
Location: Bochum, Germany and local Ruhr RESOLV partner institutions
Language of instruction: English
Costs: RESOLV sponsors travel and a monthly stipend
Period research stay: choose a time between February 2024 – August 2025