Computational engineering of enzymes: Optimizing the stability and activity of Alpha-amylase in organic solvents for the bioremediation of n-alkanes

About the group:

We are the Computational Bioengineering group at the Biochemical and Chemical Engineering department of the TU Dortmund University. The implementation and application of novel computational tools are central to our research. We focus on free energy, multiscale and machine learning-based tools, including our CL-FEP¹ approach and the PPI-Detect² and PPI-Affinity³ tools. On the application side, we focus on solvation chemistry, biocatalysis, chemical reactivity and computer aided drug design.

What they are looking for in students:

-Chemistry and biochemistry knowledge, with emphasis on protein engineering and biocatalysis

-Sound theoretical knowledge and applied skills on structure prediction and biomolecular simulations: homology models, docking techniques, molecular dynamics simulations, free energy calculations, computational mutagenesis

-Knowledge of Linux and basic scripting

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