Sánchez García Group

Computational engineering of enzymes: Optimizing the stability and activity of Alpha-amylase in organic solvents for the bioremediation of n-alkanes

About the group:

We are the Computational Bioengineering group at the Biochemical and Chemical Engineering department of the TU Dortmund University. The implementation and application of novel computational tools are central to our research. We focus on free energy, multiscale and machine learning-based tools, including our CL-FEP1 approach and the PPI-Detect2 and PPI-Affinity3 tools. On the application side, we focus on solvation chemistry, biocatalysis, chemical reactivity and computer aided drug design.

What they are looking for in students:

-Chemistry and biochemistry knowledge, with emphasis on protein engineering and biocatalysis

-Sound theoretical knowledge and applied skills on structure prediction and biomolecular simulations: homology models, docking techniques, molecular dynamics simulations, free energy calculations, computational mutagenesis

-Knowledge of Linux and basic scripting

Visit the website!

Paper related to the topic

HOW To Apply

Apply here

For your application you will need:

  • CV with contact details and affiliation (max. 2 pages)
  • letter of motivation related to Solvation Science (1 page)
  • your research proposal (1 page)
  • your diploma (Bachelor or Master)

Prerequisites: Current Master and PhD students with experience in Natural Sciences, Medical Sciences or related topics of Engineering

Start: 09th October 2023

Deadline: 01st June 2024





Win A research Stay

Subject: conduct your research proposal
Duration: 3 months
Location: Bochum, Germany and local Ruhr RESOLV partner institutions
Language of instruction: English
Costs: RESOLV sponsors travel and a monthly stipend
Period research stay: before August 2025