Ebbinghaus Group

Chaperone activity studies in living C. elegans

About the topic:

Most biomolecules function inside the cell. However, biochemical assays and analytical tools are mainly applied in vitro, in aqueous buffer solutions or crystals. Our research aim is to discover novel biochemical function by studying biomolecular reactions directly in cells under health and disease conditions. To analyze biomolecular reactions in vivo with high spatio-temporal resolution, we developed novel in-cell spectroscopic and microscopic techniques that range from temperature-induced relaxation to single molecule spectroscopy. We apply the methods in solvent environments of increasing complexity ranging from cytomimetic media and bacteria to (neuronal) cells and multicellular organisms. We currently investigate chaperone activity in C. elegans; for this project we need a team player to implement the analysis of in-cell folding data. 

What they are looking for in students:

From the applicant we would expect a high motivation to engage in the development of an instrument that can explore unresolved and urging questions in life sciences. A basic knowledge and interest in Python programming is required.

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Paper related to the topic

HOW To Apply

Apply here

For your application you will need:

  • CV with contact details and affiliation (max. 2 pages)
  • letter of motivation related to Solvation Science (1 page)
  • your research proposal (1 page)
  • your diploma (Bachelor or Master)

Prerequisites: Current Master and PhD students with expiriences in Natural Sciences, Medical Sciences or related topics of Engineering

Start: 09th October 2023

Deadline: 01st June 2024



Win A research Stay

Subject: conduct your research proposal
Duration: 3 months
Location: Bochum, Germany and local Ruhr RESOLV partner institutions
Language of instruction: English
Costs: RESOLV sponsors travel and a monthly stipend
Period research stay: before August 2025