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Internal dynamics in the active center of an enzyme believed to be rigid
Angew. Chem.: Carboanhydrase hCAII has found its way into the textbooks of drug discovery as a drug target with a particularly rigid active pocket. With the help of detailed NMR spectroscopic analysis, the group of Prof. R. Linser has now been able to show that this picture needs to be revised, which advises caution when interpreting classical structural data for estimating the "dynamic…