Angew. Chem. Int. Ed.: RESOLV PI Prof. G. Clever and RESOLV member Prof. M. Kasanmascheff developed a precise method to measure distances in DNA G-quadruplexes, advancing drug design by revealing how candidate molecules bind to these biologically important structures
Angew. Chem.: Carboanhydrase hCAII has found its way into the textbooks of drug discovery as a drug target with a particularly rigid active pocket. With the help of detailed NMR spectroscopic analysis, the group of Prof. R. Linser has now been able to show that this picture needs to be revised, which advises caution when interpreting classical structural data for estimating the "dynamic…
J. Am. Chem. Soc.: RESOLV member Prof. R. Kramer Campen's study presents the development of a novel optoelectronic technique for the characterization of the birth and structural evolution of solvated electrons at the metal/liquid interface with a femtosecond time resolution.
PNAS: A small but important step towards a successful immune reaction is performed by an impressive nanomachine. Researchers use simulations to understand how it works.
Angew.Chem.: Bacterial enzymes are often powerful but also very sensitive catalysts. To call up their performance, they therefore need a special environment.
PNAS: In hydrogenase enzymes, the transports of protons and electrons have been considered to be separate events until now. However, coupling is the key to success here.