A Bidentate Iodine(III)-Based Halogen-Bond Donor as a Powerful Organocatalyst
Angew. Chem. Int. Ed.: RESOLV member Prof. Stefan M. Huber's study presents the first application of a bidentate iodine(III)-based halogen bond donor as organocatalyst.
By contrasting their performance with that of monodentate iodine(III) and iodine(I) analogs, this study explores the potential of bidentate iodine(III)-based halogen-bond (XB) donors as extremely efficient organocatalysts. According to the study, even with previously unactivated substrates, the bidentate iodine(III)-based XB donor has excellent catalytic activity and outperforms its rivals. This is evident in reactions such as Michael, nitro-Michael, and Diels-Alder. The bidentate contact provides better selectivity and control by lowering the catalytic activation barrier, according to structural studies and DFT simulations.
