RUHR EXPLORES SOLVATION SCIENCE

RUHR EXPLORES SOLVATION SCIENCE

We shape a new scientific discipline, inspire the scientists of tomorrow, and enable future technologies

WE ARE RESOLV

WE ARE RESOLV

Over 200 scientists from about 50 research groups in 7 institutions

ZEMOS: Home of Solvation Science @RUB

ZEMOS: Home of Solvation Science @RUB

The first research building for Solvation Science in the world. Hosts over 100 scientists, it's home to 6 disciplines.

WHAT is RESOLV?

The Cluster of Excellence RESOLV is a joint research project of about fifty research groups from seven institutions in the German Ruhr area. Since 2012, we use cutting-edge experimental and computational techniques to understand the role of solvents at the molecular detail in the most diverse chemical processes. For example, we investigate the influence of water in vital biological processes as well as the effects of solvents on synthesis and catalytic reactions. Our research lays the foundations for major advances in key green and medical technologies. RESOLV is funded with 28 Mio. EUR by the German Research Foundation (DFG).

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Therapy approach for Huntington’s disease

Rubin Magazine: Computer simulations and experiments with cells have yielded promising results.

Involuntary movements are a prominent symptom of Huntington’s disease. The hereditary disease develops slowly at first, but sooner or later severely impacts those affected and ultimately leads to death. An effective drug does not yet exist.

Researchers from RUB and the University of Duisburg-Essen (UDE) have now discovered a potential therapy approach. The cause of Huntington’s disease is a defect in the huntingtin gene, in which a certain gene sequence occurs repeatedly – too many repetitions trigger the disease. The huntingtin gene contains the blueprint for the protein of the same name. Abnormal huntingtin proteins clump together, and these aggregates have a toxic effect.

Positive effects on cell cultures

UDE researchers Prof Dr Thomas Schrader and Prof Dr Frank-Gerrit Klärner have developed a synthetic molecule that has the potential to become an effective drug. In simulations, Prof Dr Elsa Sánchez-García, also at UDE, showed that the molecule can prevent the clumping of huntingtin. In cooperation with the Bochum-based biochemist Prof Dr Simon Ebbinghaus, she examined the substance in more detail.

It was effective not just in simulations. The substance also reduced the number of abnormal huntingtin aggregates in experiments with living cells. Bochum-based physicians at the St. Josefs Hospital have shown that positive effects on cell cultures are also detectable. The researchers now want to investigate the mode of action in more detail and explore the potential as a drug further.

The teams in Bochum and Duisburg-Essen collaborate within the Cluster of Excellence “Ruhr explores Solvation”.

Read this article and more in Rubin

------------------

Original publication

Tobias Vöpel et al.: Inhibition of Huntingtin Exon-1 Aggregation by the Molecular Tweezer CLR01, in: Journal of the Americal Chemical Society, 2017, DOI: 10.1021/jacs.6b11039

 

 

Posted on

Therapy approach for Huntington’s disease

Rubin Magazine: Computer simulations and experiments with cells have yielded promising results.

Involuntary movements are a prominent symptom of Huntington’s disease. The hereditary disease develops slowly at first, but sooner or later severely impacts those affected and ultimately leads to death. An effective drug does not yet exist.

Researchers from RUB and the University of Duisburg-Essen (UDE) have now discovered a potential therapy approach. The cause of Huntington’s disease is a defect in the huntingtin gene, in which a certain gene sequence occurs repeatedly – too many repetitions trigger the disease. The huntingtin gene contains the blueprint for the protein of the same name. Abnormal huntingtin proteins clump together, and these aggregates have a toxic effect.

Positive effects on cell cultures

UDE researchers Prof Dr Thomas Schrader and Prof Dr Frank-Gerrit Klärner have developed a synthetic molecule that has the potential to become an effective drug. In simulations, Prof Dr Elsa Sánchez-García, also at UDE, showed that the molecule can prevent the clumping of huntingtin. In cooperation with the Bochum-based biochemist Prof Dr Simon Ebbinghaus, she examined the substance in more detail.

It was effective not just in simulations. The substance also reduced the number of abnormal huntingtin aggregates in experiments with living cells. Bochum-based physicians at the St. Josefs Hospital have shown that positive effects on cell cultures are also detectable. The researchers now want to investigate the mode of action in more detail and explore the potential as a drug further.

The teams in Bochum and Duisburg-Essen collaborate within the Cluster of Excellence “Ruhr explores Solvation”.

Read this article and more in Rubin

------------------

Original publication

Tobias Vöpel et al.: Inhibition of Huntingtin Exon-1 Aggregation by the Molecular Tweezer CLR01, in: Journal of the Americal Chemical Society, 2017, DOI: 10.1021/jacs.6b11039

 

 

Our scientific fields

Research Area A

Understanding and Exploiting Solvation in Chemical Processes

 

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Research Area B

Connecting Solvation Dynamics with Biomolecular Function

 

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Research Area C

Ion Solvation
and Charge Transfer at Interfaces

 

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Video: The solvent of life

Water. It’s the most abundant substance on Earth´s surface and in our bodies. But is water a passive spectator in the animated scene of bio-chemical reactions inside our cells? RESOLV scientists investigate the important role that water plays in the most diverse processes, bringing solvation science into the spotlight.

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Posted on

Therapy approach for Huntington’s disease

Rubin Magazine: Computer simulations and experiments with cells have yielded promising results.

Involuntary movements are a prominent symptom of Huntington’s disease. The hereditary disease develops slowly at first, but sooner or later severely impacts those affected and ultimately leads to death. An effective drug does not yet exist.

Researchers from RUB and the University of Duisburg-Essen (UDE) have now discovered a potential therapy approach. The cause of Huntington’s disease is a defect in the huntingtin gene, in which a certain gene sequence occurs repeatedly – too many repetitions trigger the disease. The huntingtin gene contains the blueprint for the protein of the same name. Abnormal huntingtin proteins clump together, and these aggregates have a toxic effect.

Positive effects on cell cultures

UDE researchers Prof Dr Thomas Schrader and Prof Dr Frank-Gerrit Klärner have developed a synthetic molecule that has the potential to become an effective drug. In simulations, Prof Dr Elsa Sánchez-García, also at UDE, showed that the molecule can prevent the clumping of huntingtin. In cooperation with the Bochum-based biochemist Prof Dr Simon Ebbinghaus, she examined the substance in more detail.

It was effective not just in simulations. The substance also reduced the number of abnormal huntingtin aggregates in experiments with living cells. Bochum-based physicians at the St. Josefs Hospital have shown that positive effects on cell cultures are also detectable. The researchers now want to investigate the mode of action in more detail and explore the potential as a drug further.

The teams in Bochum and Duisburg-Essen collaborate within the Cluster of Excellence “Ruhr explores Solvation”.

Read this article and more in Rubin

------------------

Original publication

Tobias Vöpel et al.: Inhibition of Huntingtin Exon-1 Aggregation by the Molecular Tweezer CLR01, in: Journal of the Americal Chemical Society, 2017, DOI: 10.1021/jacs.6b11039

 

 

gss summer school

The Graduate School Solvation Science hosts an annual Summer School at the Ruhr University Bochum. The school always takes place during Whitsuntide and is an integral part of the GSS students' training during their doctoral studies. The fourth GSS Summer School took place from the 6th to the 9th of June, 2017.

International speakers, suggested by the students themselves, are invited to give keynote talks on their research in the field of Solvation Science. The Advanced Laboratory Modules give the students an excellent opportunity to learn new and interesting experimental and theoretical techniques within a specific research topic of their own choice. In 2017 the program of the Summer School comprised a career day, in addition.

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Publications highlight

T. Schleif, J. Mieres-Perez, S. Henkel, M. Ertelt, W. T. Borden, W. Sander
The Cope Rearrangement of 1,5-Dimethylsemibullvalene-2(4)-d1: Experimental Evidence for Heavy-Atom Tunneling
Angew. Chem. 129 (2017), 10886
DOI: 10.1002/ange.201704787 

K. F. Pfister, S. Baader, M. Baader, S. Berndt, L. J. Goossen
Biofuel by isomerizing metathesis of rapeseed oil esters with (bio)ethylene for use in contemporary dieses engines
Science Advances  3 (2017),  e1602624
DOI: 10.1126/sciadv.1602624

C. Schuabb, N. Kumar, S. Pataraia, D. Marx, R. Winter
Pressure modulates the self-cleavage step of the hairpin ribozyme
Nature Communications 8 (2017), 14661
DOI: 10.1038/ncomms14661

 

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