Using cutting-edge high-throughput sequencing methods, researchers have mapped all RNA structures of a diarrhoeal pathogen at once. In the process, they identified a number of temperature-responsive structures, so-called RNA thermometers. “To date, we only ever discovered individual RNA thermometers following a tedious search, and painstakingly analysed one after the other,” says project manager Prof Dr Franz Narberhaus from Ruhr-Universität Bochum.