Chem. Eur. J.: RESOLV members, Prof. Dr. Roland Winter and Prof. Dr. Jörg Tatzelt unveil an AMP-Based Strategy to Disrupt SARS-CoV-2 Replication in this article. Antimicrobial peptides (AMPs) may offer a novel antiviral approach by interfering with key viral protein condensates, according to their findings. The study reveals how three AMPs, including LL–III, CrACP1, and GKY20, interfere with N–P/RNA condensates in distinct ways, from altering droplet morphology to forming fibrillar structures. These disruptions could hinder virion assembly, opening new avenues for AMP-based antiviral therapies.
