Organocatalytic stereoselective cyanosilylation of small ketones
Nature: RESOLV PI Prof. B. List reports the development of broadly applicable confined organocatalysts for the highly enantioselective cyanosilylation of aromatic and aliphatic ketones.
The study tackles the problem of using chemical catalysts to achieve enzymatic-like stereoselectivity, particularly in the cyanosilylation of tiny ketones. Imidodiphosphorimidate (IDPi)-based restricted organocatalysts were created by the researchers to facilitate the extremely enantioselective cyanosilylation of aliphatic and aromatic ketones, including the difficult 2-butanone. Achieving hitherto unheard-of selectivity (up to 99:1 enantiomeric ratio) for 2-butanone surpasses even built biocatalysts, according to key discoveries.
