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Folding experiments in densely packed solutions in the test tube as well as in the living cell facilitate the monitoring of the stability of an RNA hairpin at high spatial and temporal resolution. © RUB, David Gnutt

RNA HAIRPIN FOLDING IN THE CROWDED CELL

Angew. Chem.: The RESOLV groups of Prof. Dr. Simon Ebbinghaus (RUB) and Prof. Dr. Roland Winter (TU Dortmund) report their results in "Angewandte Chemie" together with colleagues at the RUB Department of Biology and at the Ernst Moritz Arndt University of Greifswald.

Researchers often analyse isolated biomolecules in test tubes, and it is doubtful if the results can be applied to densely-packed cells. A team from Bochum, Dortmund and Greifswald monitored the folding of an RNA structure in the living cell and compared the results with those of test tube analyses.

The team studied the behaviour of an RNA structure from the microorganism Salmonella in three different scenarios: in a living cell; in an aqueous solution without additives; and in an aqueous solution with various additives that were supposed to mimic the molecules in the cells.

 

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