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Green algae possess an enzyme for producing hydrogen, called hydrogenase. Together with his colleagues, Thomas Happe engineers such enzymes in the test tube. © RUB, Marquard

NEW INSIGHTS INTO HYDROGENASE COFACTOR ASSEMBLY

Angew. Chem.: The team around RESOLV PS Prof. Thomas Happe gained new insights into the cofactor assembly of hydrogenase.

Researchers from Bochum have engineered a hydrogen-producing enzyme in the test tube that works as efficiently as the original. The protein – a so-called hydrogenase from green algae – is made up of a protein scaffold and a cofactor. The latter is the reaction centre where the substances that react with each other dock. When the researchers added various chemically synthesised substances to the protein scaffold, the cofactor spontaneously assembled. 

 

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