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Stephanie Bleicken researches the complex interplay of proteins. © RUB, Kramer

How protein interactions drive cellular death

Nat. Comm.: Researchers use a simplified model of a protein network to explain how apoptosis is regulated, whose malfunction is linked to cancer and neurodegenerative diseases.

Researchers at the Universities of Tübingen and Konstanz, the Ruhr-Universität Bochum, the Max Planck Institute of Intelligent Systems in Stuttgart, and the German Cancer Research Centers have worked together to gain new insights into a protein network which regulates the programmed break down of cells, also known as apoptosis. These Bcl-2 proteins are difficult to investigate as they exchange between the cell’s watery cytoplasm and its oil-like membranes.

 

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