RUHR EXPLORES SOLVATION SCIENCE

RUHR EXPLORES SOLVATION SCIENCE

We shape a new scientific discipline, inspire the scientists of tomorrow, and enable future technologies

WE ARE RESOLV

WE ARE RESOLV

Over 200 scientists from about 50 research groups in 7 institutions

ZEMOS: Home of Solvation Science @RUB

ZEMOS: Home of Solvation Science @RUB

The first research building for Solvation Science in the world. Hosts over 100 scientists, it's home to 6 disciplines.

WHAT is RESOLV?

The Cluster of Excellence RESOLV is a joint research project of about fifty research groups from seven institutions in the German Ruhr area. Since 2012, we use cutting-edge experimental and computational techniques to understand the role of solvents at the molecular detail in the most diverse chemical processes. For example, we investigate the influence of water in vital biological processes as well as the effects of solvents on synthesis and catalytic reactions. Our research lays the foundations for major advances in key green and medical technologies. RESOLV is funded with 28 Mio. EUR by the German Research Foundation (DFG).

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#ASKTHEAUTHOR: How the solvent affects supramolecular structures

Angew. Chem. Int. Ed.: 3 Questions to RESOLV and TU Dortmund scientist Guido Clever about his recent publication in 'Angewandte Chemie International Edition' on hierarchical supramolecular assemblies.

 

1. What is the new discovery that you made?

In our research, we use transition metal cations and banana-shaped organic molecules as building blocks to form and functionalise nano-sized rings and cages. In this publication we have found that certain Palladium-based structures form only in a distinct solvent, whereas in other solvents the formation seems to be disfavoured. For the first time, we were now able to obtain a M8L16 metallo-supramolecular catenane (made by two entangled rings; M = metal, L = ligand). To elucidate its structure, we used nuclear magnetic resonance spectroscopy, mass spectrometry and X-ray diffraction techniques.

2. What is its significance?

The significance of our findings can be illuminated from two perspectives: On the one hand, intensive research conducted by groups around the world has collected a set of rules concerning the size, shape and topology of self-assembled structures of the MnL2n-type, but catenation has never been observed for Palladium-based assemblies of this size. On the other hand, mechanically interlocked nanostructures are raising considerable interest as components of artificial molecular machines, substantiated by the 2016 Nobel Prize in Chemistry that was awarded to Sauvage, Feringa and Stoddart. Such self-assembled structures with increasing complexity promise future application as selective receptors, enzyme-mimicking catalysts and stimuli-responsive materials.

3. Is this related to Solvation Science? If yes, how?

Aside from the metal coordination geometry and various non-covalent attractive and repulsive forces, the solvent plays a major role. The importance of solvation in the stepwise assembly, catenation and aggregation of hollow supramolecular structures from simple organic molecules and metal cations, serving as a glue to join the nano-sized architectures, has been disregarded for a long time. To improve the predictability of the molecular design approaches, a deeper understanding of the solution-based formation of these compounds is needed. RESOLV gives us the possibility to examine solvation effects by a joint effort between supramolecular synthesis, state-of-the-art spectroscopy and high-level theoretical methods.

 

Original Publication:

W. M. Bloch, J. J. Holstein, B. Dittrich, W. Hiller, G. H. Clever,  Hierarchical Assembly of an Interlocked M8L16 Container, Angew. Chem. Int. Ed. 2018

DOI: 10.1002/anie.201800490

Posted on

#ASKTHEAUTHOR: How the solvent affects supramolecular structures

Angew. Chem. Int. Ed.: 3 Questions to RESOLV and TU Dortmund scientist Guido Clever about his recent publication in 'Angewandte Chemie International Edition' on hierarchical supramolecular assemblies.

 

1. What is the new discovery that you made?

In our research, we use transition metal cations and banana-shaped organic molecules as building blocks to form and functionalise nano-sized rings and cages. In this publication we have found that certain Palladium-based structures form only in a distinct solvent, whereas in other solvents the formation seems to be disfavoured. For the first time, we were now able to obtain a M8L16 metallo-supramolecular catenane (made by two entangled rings; M = metal, L = ligand). To elucidate its structure, we used nuclear magnetic resonance spectroscopy, mass spectrometry and X-ray diffraction techniques.

2. What is its significance?

The significance of our findings can be illuminated from two perspectives: On the one hand, intensive research conducted by groups around the world has collected a set of rules concerning the size, shape and topology of self-assembled structures of the MnL2n-type, but catenation has never been observed for Palladium-based assemblies of this size. On the other hand, mechanically interlocked nanostructures are raising considerable interest as components of artificial molecular machines, substantiated by the 2016 Nobel Prize in Chemistry that was awarded to Sauvage, Feringa and Stoddart. Such self-assembled structures with increasing complexity promise future application as selective receptors, enzyme-mimicking catalysts and stimuli-responsive materials.

3. Is this related to Solvation Science? If yes, how?

Aside from the metal coordination geometry and various non-covalent attractive and repulsive forces, the solvent plays a major role. The importance of solvation in the stepwise assembly, catenation and aggregation of hollow supramolecular structures from simple organic molecules and metal cations, serving as a glue to join the nano-sized architectures, has been disregarded for a long time. To improve the predictability of the molecular design approaches, a deeper understanding of the solution-based formation of these compounds is needed. RESOLV gives us the possibility to examine solvation effects by a joint effort between supramolecular synthesis, state-of-the-art spectroscopy and high-level theoretical methods.

 

Original Publication:

W. M. Bloch, J. J. Holstein, B. Dittrich, W. Hiller, G. H. Clever,  Hierarchical Assembly of an Interlocked M8L16 Container, Angew. Chem. Int. Ed. 2018

DOI: 10.1002/anie.201800490

Our scientific fields

Research Area A

Understanding and Exploiting Solvation in Chemical Processes

 

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Research Area B

Connecting Solvation Dynamics with Biomolecular Function

 

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Research Area C

Ion Solvation
and Charge Transfer at Interfaces

 

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Video: The solvent of life

Water. It’s the most abundant substance on Earth´s surface and in our bodies. But is water a passive spectator in the animated scene of bio-chemical reactions inside our cells? RESOLV scientists investigate the important role that water plays in the most diverse processes, bringing solvation science into the spotlight.

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Posted on

#ASKTHEAUTHOR: How the solvent affects supramolecular structures

Angew. Chem. Int. Ed.: 3 Questions to RESOLV and TU Dortmund scientist Guido Clever about his recent publication in 'Angewandte Chemie International Edition' on hierarchical supramolecular assemblies.

 

1. What is the new discovery that you made?

In our research, we use transition metal cations and banana-shaped organic molecules as building blocks to form and functionalise nano-sized rings and cages. In this publication we have found that certain Palladium-based structures form only in a distinct solvent, whereas in other solvents the formation seems to be disfavoured. For the first time, we were now able to obtain a M8L16 metallo-supramolecular catenane (made by two entangled rings; M = metal, L = ligand). To elucidate its structure, we used nuclear magnetic resonance spectroscopy, mass spectrometry and X-ray diffraction techniques.

2. What is its significance?

The significance of our findings can be illuminated from two perspectives: On the one hand, intensive research conducted by groups around the world has collected a set of rules concerning the size, shape and topology of self-assembled structures of the MnL2n-type, but catenation has never been observed for Palladium-based assemblies of this size. On the other hand, mechanically interlocked nanostructures are raising considerable interest as components of artificial molecular machines, substantiated by the 2016 Nobel Prize in Chemistry that was awarded to Sauvage, Feringa and Stoddart. Such self-assembled structures with increasing complexity promise future application as selective receptors, enzyme-mimicking catalysts and stimuli-responsive materials.

3. Is this related to Solvation Science? If yes, how?

Aside from the metal coordination geometry and various non-covalent attractive and repulsive forces, the solvent plays a major role. The importance of solvation in the stepwise assembly, catenation and aggregation of hollow supramolecular structures from simple organic molecules and metal cations, serving as a glue to join the nano-sized architectures, has been disregarded for a long time. To improve the predictability of the molecular design approaches, a deeper understanding of the solution-based formation of these compounds is needed. RESOLV gives us the possibility to examine solvation effects by a joint effort between supramolecular synthesis, state-of-the-art spectroscopy and high-level theoretical methods.

 

Original Publication:

W. M. Bloch, J. J. Holstein, B. Dittrich, W. Hiller, G. H. Clever,  Hierarchical Assembly of an Interlocked M8L16 Container, Angew. Chem. Int. Ed. 2018

DOI: 10.1002/anie.201800490

gss summer school

The Graduate School Solvation Science hosts an annual Summer School at the Ruhr University Bochum. The school always takes place during Whitsuntide and is an integral part of the GSS students' training during their doctoral studies. This year's GSS Summer School took place from the 22nd to the 25th of May, 2018.

International speakers, suggested by the students themselves, are invited to give keynote talks on their research in the field of Solvation Science. The Advanced Laboratory Modules give the students an excellent opportunity to learn new and interesting experimental and theoretical techniques within a specific research topic of their own choice. 

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Publications highlight

K Lucht, D Loose, M Ruschmeier, V Strotkötter, G Dyker, K Morgenstern
Hydrophilicity and Microsolvation of an Organic Molecule Resolved on the Submolecular Level by Scanning Tunneling Microscopy, Angew. Chem. 57 (2018), 1266, DOI: 10.1002/anie.201711062

N Tsuji, JL Kennemur, T Buyck, S Lee, S Prévost, PSJ Kaib, D Bykov, C Farès, B List
Activation of olefins via asymmetric Brøsted acid, Science 359 (2018), 1501, DOI: 10.1126/science.aaq0445

D Muñoz-santiburcio, M Farnesi Camellone, D Marx
Solvation-Induced Changes in the Mechanism of Alcohol Oxidation at Gold/Titania Nanocatalysts in the Aqueous Phase versus Gas Phase, Angew. Chem. 57 (2018), 3327, DOI: 10.1002/anie.201710791

KF Pfister, S Baader, M Baader, S Berndt, LJ Goossen
Biofuel by isomerizing metathesis of rapeseed oil esters with (bio)ethylene for use in contemporary dieses engines, Science Advances  3 (2017),  e1602624, DOI: 10.1126/sciadv.1602624

C Schuabb, N Kumar, S Pataraia, D Marx, R Winter
Pressure modulates the self-cleavage step of the hairpin ribozyme, Nature Communications 8 (2017), 14661, DOI: 10.1038/ncomms14661

 

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